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The synthesis of 1H-pyrazol-4-ols from 2-(2-alkylidenehydrazino)acetic acids
Institution:1. Department of Chemical Research, Merck Research Laboratories, 126 E. Lincoln Ave., Rahway, NJ 07065, USA;2. Department of Chemical Research, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA;3. Department of Chemical Research, Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486, USA;1. School of Chemical and Environmental Engineering, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai 201418, PR China;2. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, PR China;1. Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche, Via Archirafi 32, 90123 Palermo, Italy;2. Department of Organic Chemistry, Semmelweis University, Högyes E. u. 7, H-1092 Budapest, Hungary;1. Respiratory, Inflammation & Autoimmunity, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Pepparedsleden 1, Mölndal, 43183, Sweden;2. Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Pepparedsleden 1, Mölndal, 43183, Sweden
Abstract:A new general method for synthesizing 1H-pyrazol-4-ols by cyclizing2-(2-alkylidenehydrazino) acetic acids with acetic anhydride in pyridine is reported.
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