The biosynthesis of the antibiotic obafluorin from p-aminophenylalanine in Pseudomonas fluorescens期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

The biosynthesis of the antibiotic obafluorin from p-aminophenylalanine in Pseudomonas fluorescens

Affiliation:	1. Fundación Instituto de Inmunología de Colombia (FIDIC), Bogotá, Colombia;2. PhD Programme in Biomedical and Biological Sciences, Universidad del Rosario, Bogotá, Colombia;3. Universidad de Boyacá, Tunja, Colombia;4. School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia;5. Universidad de Ciencias Aplicadas y Ambientales (U.D.C.A), Bogotá, Colombia;6. Universidad Nacional de Colombia, Bogotá, Colombia;1. Department of Chemistry, Banasthali University, Rajasthan 304022, India;2. Science Block, N.B.G.S.M. College, Gurugram University, Gurugram 122103, India;3. School of Chemical Sciences, Central University of Gujarat, Gandhinagar 382030, India;1. College of Nursing, King Saud University, Riyadh, Saudi Arabia;2. College of Education, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia;3. Medicinal, Aromatic and Poisonous Plants Research Center (MAPRC), College of Pharmacy, King Saud University, Riyadh, Saudi Arabia;1. Dipartimento di Agraria, University of Sassari, via E. De Nicola, 07100 Sassari, Italy;2. Bioecopest Srl, Technology Park of Sardinia, Tramariglio, 07041 Alghero, Italy

Abstract:	The separate units which are used to construct the unique β-lactone antibiotic obafluorin (1) in Pseudomonas fluorescens are defined by the results of [U-¹³C]glucose incorporation. A key intermediate in the biosynthesis of (1) is established to be L-p-aminophenylalanine (7); L-p-nitrophenylalanine (8) is a relatively insignificant precursor. Similar results were obtained for p-nitrophenylacetic acid (9) which is also a metabolite of Ps. fluorescens. L-phenylalanine is an insignificant precursor for obafluorin (1).

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