| Abstract: | A model for protein adsorption kinetics is presented. This model includes diffusion limited adsorption, adsorption and desorption rate constants which are dependent on the surface concentration and an interaction term for the mutual influence of the adsorbed protein molecules. It is shown that, in first approximation, the values of the adsorption and desorption rate constants are exponential functions of the surface concentration. Assuming an adequate interaction term it is possible to show with this model for the adsorption kinetics of a mixture of proteins that the ratio of the adsorbed proteins is strongly dependent on the overall surface concentration even if the ratio of the bulk concentrations of these proteins is kept constant. Differences in interaction terms for the different proteins offer a possible explanation for the peculiar behaviour of plasma protein adsorption on a surface at different dilutions of the plasma, the so called “Vroman effect”. |
