Cyclopentane synthesis and annulation: Intramolecular radical cyclization of acetals |
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| Affiliation: | 1. Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany;2. Department of Pharmaceutical and Medicinal Chemistry, Nnamdi Azikiwe University, Awka, Nigeria;3. Institute of Physiological Chemistry, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, 55128 Mainz, Germany;4. Institute of Complex Systems: Strukturbiochemie, Forschungszentrum Juelich, 52428 Juelich, Germany |
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| Abstract: | A general procedure for cyclopentane synthesis based on free-radical cyclization of thioacetals is described. This permits the rapid assembly, by intramolecular annulation, of various ring systems bearing useful functionality for use in total synthesis. |
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