Medium and structural effects on the ionization constants of some pyrazole carboxylic acid derivatives |
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| Authors: | Sibel Alkan Bülent Zeybek Alev Doğan Rahmi Kasımoğulları Yunus Erdoğan Esma Kılıç |
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| Affiliation: | (1) Department Chemistry, Faculty of Arts and Sciences, Dumlupınar University, Kutahya, Turkey;(2) Department Chemistry, Faculty of Science, Ankara University, Ankara, Turkey;(3) Faculty of Gazi Education, Gazi University, Ankara, Turkey |
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| Abstract: | Abstract Stoichiometric ionization constants of some pyrazole carboxylic acids [4-benzoyl-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid, 4-benzoyl-1-(4-nitrophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid, 4-(ethoxycarbonyl)-1,5-diphenyl-1H-pyrazole-3-carboxylic acid, 4-(ethoxycarbonyl)-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid, 4-(ethoxycarbonyl)-1-(4-nitrophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid] were determined in ethanol–water mixtures of 50, 60, 70% ethanol (v/v) by a potentiometric titration method. Titrations were performed in an ionic strength of 0.10 M NaCl at 25.0 ± 0.1 °C using an Orion 960 automatic titrator under a nitrogen atmosphere. Using the potentiometric titration data, ionization constants were calculated in three different ways. The effects of structure and solvent on the acidity of pyrazole carboxylic acids are also discussed. Graphical abstract  |
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| Keywords: | Pyrazole carboxylic acid Ethanol– water mixtures Solvent effect Ionization constants Potentiometry |
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