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One-step assembly of carbamoyl-substituted heteroannelated [1,4]thiazepines |
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| Authors: | Ilyn Alexey P Loseva Marina V Vvedensky Vladimir Y Putsykina Elena B Tkachenko Sergey E Kravchenko Dmitri V Khvat Alexandr V Krasavin Mikhail Y Ivachtchenko Alexandre V |
| Affiliation: | Department of Organic Chemistry, Chemical Diversity Research Institute, 114401 Khimki, Moscow Reg., Russia. |
| Abstract: | We present a convenient synthesis of novel heteroaryl-fused 3-oxo-1,4-thiazepine-5-carboxamides and 5-oxo-1,4-thiazepine-3-carboxamides using a modification of four-component Ugi condensation. We demonstrate the usefulness and versatility of the developed approach for the synthesis of variously substituted compounds and discuss the scope and limitations of the chemistry involved. |
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