Efficient oxidation of cysteine and glutathione catalyzed by a dinuclear areneruthenium trithiolato anticancer complex |
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| Authors: | Giannini Federico Süss-Fink Georg Furrer Julien |
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| Affiliation: | Departement für Chemie und Biochemie, Universit?t Bern, CH-3012 Bern, Switzerland. |
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| Abstract: | The highly cytotoxic diruthenium complex [(p-MeC(6)H(4)Pr(i))(2)Ru(2)(SC(6)H(4)-p-Me)(3)](+) (1), water-soluble as the chloride salt, is shown to efficiently catalyze oxidation of the thiols cysteine and glutathione to give the corresponding disulfides, which may explain its high in vitro anticancer activity. |
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