Parallel synthesis of glycomimetic libraries: targeting a C-type lectin |
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Authors: | Schuster Michael C Mann David A Buchholz Tonia J Johnson Kathryn M Thomas William D Kiessling Laura L |
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Institution: | Departments of Chemistry and Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA. |
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Abstract: | We have developed methods for the parallel synthesis of two libraries of non-carbohydrate-based analogues of mannose on a solid support. The natural product shikimic acid was used as a key building block. The ability of the compounds to block the binding of the C-type lectin MBP-A to a mannosylated surface was assessed in a high-throughput assay. Ten library members with inhibitory activities equivalent to that of alpha-methyl mannopyranoside were identified. reaction: see text] |
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