Pharmacokinetics of brain natriuretic peptide in rats. |
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| Authors: | Y Hashimoto K Nakao N Hama M Mukoyama H Imura M Yasuhara R Hori |
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| Institution: | Department of Pharmacy, Kyoto University Hospital, Japan. |
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| Abstract: | The pharmacokinetics of rat brain natriuretic peptide (rBNP) was compared with that of alpha-rat atrial natriuretic peptide (alpha-rANP) in rats. After intravenous infusion in rats (600 pmol min-1kg-1 for 2 min), the disappearance of plasma rBNP was 4-fold slower than that of alpha-rANP. The estimated mean plasma clearance rates for rBNP and alpha-rANP were 45.9 ml min-1kg-1 and 74.4 ml min-1kg-1, respectively. The affinity of rBNP for the clearance receptor or degradation enzyme was considered to be lower than that of alpha-rANP. |
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