Total synthesis of apratoxin A |
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| Authors: | Chen Jiehao Forsyth Craig J |
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| Affiliation: | Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA. |
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| Abstract: | Apratoxin A, a cyclodepsipeptide isolated from cyanobacterial Lyngbya spp, has been synthesized. The total synthesis features stereocontrolled access to the novel polyketide and the late-stage installation of the sensitive 2,4-disubstituted thiazoline moiety using an intramolecular Staudinger reduction/aza-Wittig process. |
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