| Synthesis of a New Cerebroside Isolated from Typhonium giganteum Engl |
| |
| 作者姓名： | 陈雪松 吴毓林 陈迪华 |
| |
| 作者单位： | State Key Laboratory of Bioorganic and Natural Products Chemistry，Shanghai Institute of Organic Chemistry，Chinese Acdemy of Sciences，Shanghai 20002，China Institute of Medicinal Plant Development，Chinese Academy of Medical Sciences & Peking Union Medical College，Beijing 100094，China，State Key Laboratory of Bioorganic and Natural Products Chemistry，Shanghai Institute of Organic Chemistry，Chinese Academy of Sciences，Shanghai 200032，China，Institute of Medicinal Plant Development，Chinese Academy of Medical Sciences & Peking Union Medical College，Beijing 100094，China |
| |
| 基金项目： | Project supported by the National Natural Science Foundation of China(No.29790126),Chinese Academy of Sciences(No.95-A1504-03)and the Ministry of Science and Technology of China(Nos.970211006-6,G2000077502). |
| |
| 摘 要： | The stereoselecfive synthesis of typhoniside, a new cerebroside isolated from Typhonium giganteum Engl. was accomplished.Cerebrosides are a kind of glycolipids highly enriched on the surface of myelin-producing cells and are composed by C18-4,8-sphingadienine, a-hydroxy acid and a saccharide head. It was the first time that cerebrosides were isolated from this traditional Chinese medicine (TCM) by us. In this paper, C18-4,8-sphingadienine was synthesized from D-xylose via a SN2 type reaction, α-Hydroxy acid was prepared from (R)-4-hydroxyte-trahydrofuran-2-one, which in turn could be obtained from Lascorbic acid.
|
| 关 键 词： | 合成 脑苷脂 天然化合物 独角莲 手性 结构表征 生物活性 |
Synthesis of a New Cerebroside Isolated from Typhonium giganteum Engl |
| |
| CHEN,Xue-Song WU,Yu-Lin CHEN,Di-Hua
State Key Laboratory of Bioorganic and Natural Products Chemistry.Synthesis of a New Cerebroside Isolated from Typhonium giganteum Engl[J].Chinese Journal of Chemistry,2003,21(7):937-943. |
| |
| Authors: | CHEN Xue-Song WU Yu-Lin CHEN Di-Hua
State Key Laboratory of Bioorganic and Natural Products Chemistry |
| |
| Institution: | CHEN,Xue-Song WU,Yu-Lin CHEN,Di-Hua
State Key Laboratory of Bioorganic and Natural Products Chemistry,Shanghai Institute of Organic Chemistry,Chinese
Academy of Sciences,Shanghai 200032,China Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing
100094,China |
| |
| Abstract: | The stereoselective synthesis of typhoniside, a new cerebroside isolated from Typhonium giganteum Engl, was accomplished. Cerebrosides are a kind of glycolipids highly enriched on the surface of myelin‐producing cells and are composed by C18–4, 8‐sphingadienine, α‐hydroxy acid and a saccharide head. It was the first time that cerebrosides were isolated from this traditional Chinese medicine (TCM) by us. In this paper, C18–4, 8‐sphingadienine was synthesized from D‐xylose via a SN2 type reaction, α‐Hydroxy acid was prepared from (R)‐4‐hydroxyte‐trahydrofuran‐2‐one, which in turn could be obtained from L‐ascorbic acid. |
| |
| Keywords: | Typhonium giganteum Engl natural product cere-broside chiron approach synthesis |
| 本文献已被 CNKI 等数据库收录！ |
|
