Tailored Cobalt‐Catalysts for Reductive Alkylation of Anilines with Carboxylic Acids under Mild Conditions |
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| Authors: | Dr. Weiping Liu Dr. Basudev Sahoo Dr. Anke Spannenberg Dr. Kathrin Junge Prof. Dr. Matthias Beller |
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| Affiliation: | Leibniz-Institut für Katalyse e.V. an der Universit?t Rostock, Rostock, Germany |
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| Abstract: | The first cobalt‐catalyzed hydrogenative N‐methylation and alkylation of amines with readily available carboxylic acid feedstocks as alkylating agents and H2 as ideal reductant is described. Combination of tailor‐made triphos ligands with cobalt(II) tetrafluoroborate significantly improved the efficiency, thus promoting the reaction under milder conditions. This novel protocol allows for a broad substrate scope with good functional group tolerance, even in the presence of reducible alkenes, esters, and amides. |
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| Keywords: | alkylation cobalt homogeneous catalysis hydrogenation tailor-made triphos |
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