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Mechanochemical Rhodium(III)‐ and Gold(I)‐Catalyzed C−H Bond Alkynylations of Indoles under Solventless Conditions in Mixer Mills |
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| Authors: | Gary N. Hermann Marvin T. Unruh Se‐Hyeong Jung Maik Krings Prof. Dr. Carsten Bolm |
| Affiliation: | 1. http://bolm.oc.rwth‐aachen.de/;2. Institute of Organic Chemistry, RWTH Aachen University, Aachen, Germany |
| Abstract: | Mechanochemical activations in RhIII‐ and AuI‐catalyzed C?H alkynylations lead selectively to C2‐ and C3‐alkynylated indoles. The processes show excellent functional group tolerance, do not require additional heating and proceed under solventless conditions. Compared to solvent‐based standard protocols, the reaction times are shorter and the catalyst quantities lower resulting in high product yields under ambient atmosphere in mixer mills. |
| Keywords: | ball mill C− H alkynylation gold catalysis mechanochemistry rhodium catalysis |