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Photoinduced Palladium‐Catalyzed Negishi Cross‐Couplings Enabled by the Visible‐Light Absorption of Palladium–Zinc Complexes |
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| Authors: | Irini Abdiaj Dr Lena Huck José Miguel Mateo Prof?Dr Antonio de?la?Hoz Dr M Victoria Gomez Prof?Dr Angel Díaz‐Ortiz Dr Jesús Alcázar |
| Institution: | 1. Discovery Sciences, Janssen Research and Development, Janssen-Cilag, S.A., Toledo, Spain;2. Facultad de Ciencias Químicas, Universidad de Castilla-La Mancha, Ciudad Real, Spain;3. Instituto Regional de Investigación Científica Aplicada, Universidad de Castilla-La Mancha, Ciudad Real, Spain |
| Abstract: | A visible‐light‐induced Negishi cross‐coupling is enabled by the activation of a Pd0–Zn complex. With this photocatalytic method, the scope of deactivated aryl halides that can be employed in the Negishi coupling was significantly expanded. NMR experiments conducted in the presence and absence of light confirmed that the formation of the palladium–zinc complex is key for accelerating the oxidative addition step. |
| Keywords: | cross-coupling flow chemistry Negishi coupling palladium catalysis photocatalysis |