HFIP‐Assisted C−H Functionalization by Cp*CoIII: Access to Key Reactive Cobaltacycles and Implication in Catalysis |
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| Authors: | Jesús Sanjosé‐Orduna Dr. Juan Manuel Sarria Toro Dr. Mónica H. Pérez‐Temprano |
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| Affiliation: | 1. Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology (BIST), Tarragona, Spain;2. Departament de Química Analítica i Química Orgànica, Universitat Rovira i Virgili, Tarragona, Spain |
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| Abstract: | Described here is a synthetic approach to access two of the most widely invoked cationic cobaltacycles in Cp*CoIII‐catalyzed C?H functionalization reactions by C?H activation. The unique stabilizing capability of MeCN was used to surmount the previously proposed reversible nature of the C?H metalation step. Moreover, it is revealed the boosting effect of 1,1,1,3,3,3‐hexafluoroisopropanol in the metalation step and in the reaction between N‐pyrimidinylindole and diphenylacetylene under catalytic conditions. |
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| Keywords: | C− H activation cobalt reaction mechanisms reactive intermediates synthetic methods |
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