Metal‐Free Direct C−H Cyanation of Alkenes |
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| Authors: | Dr Xi Wang Prof?Dr Armido Studer |
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| Institution: | Westf?lische Wilhelms-Universit?t, Organisch-Chemisches Institut, Münster, Germany |
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| Abstract: | A metal‐free and direct alkene C?H cyanation is described. Directing groups are not required and the mechanism involves electrophilic activation of the alkene by a cyano iodine(III) species generated in situ from a bis(trifluoroacetoxy)iodo]arene and trimethylsilyl cyanide as the cyanide source. This C?H functionalization can be conducted on gram scale, and for noncyclic 1,1‐ and 1,2‐disubstuted alkenes high stereoselectivity is achieved, thus rendering the method highly valuable. |
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| Keywords: | alkenes C− H functionalization cyanation hypervalent compounds synthetic methods |
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