Palladium‐Catalyzed Reductive [5+1] Cycloaddition of 3‐Acetoxy‐1,4‐enynes with CO: Access to Phenols Enabled by Hydrosilanes |
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| Authors: | Li‐Jun Wu Prof?Dr Ren‐Jie Song Prof?Dr Shenglian Luo Prof?Dr Jin‐Heng Li |
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| Institution: | 1. State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, China;2. Key Laboratory of Jiangxi Province for Persistent, Pollutants Control and Resources Recycle, Nanchang Hangkong University, Nanchang, China;3. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, China |
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| Abstract: | A new palladium‐catalyzed reductive 5+1] cycloaddition of 3‐acetoxy‐1,4‐enynes with CO, enabled by hydrosilanes, has been developed for delivering valuable functionalized phenols. This methodology employs hydrosilanes as the external reagent to facilitate the 5+1] carbonylative benzannulation. The reaction is a conceptually and mechanistically novel carbonylative cycloaddition route for the construction of substituted phenols, through the formation of four new chemical bonds, with excellent functional‐group tolerance. |
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| Keywords: | annulations enynes palladium phenols synthetic methods |
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