Asymmetric Synthesis of Tetrahydroindolizines by Bimetallic Relay Catalyzed Cycloaddition of Pyridinium Ylides |
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| Authors: | Dong Zhang Prof. Dr. Lili Lin Jian Yang Prof. Dr. Xiaohua Liu Prof. Dr. Xiaoming Feng |
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| Affiliation: | Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, China |
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| Abstract: | A highly enantioselective synthesis of tetrahydroindolizines by catalytic multicomponent cycloaddition reactions of diazoacetate, pyridine, and alkenyloxindole was developed. Under the relay catalysis, involving an achiral iron(III) catalyst and chiral N,N′‐dioxide‐scandium(III) complex, a series of tetrahydroindolizines bearing different substituents were obtained in moderate to high yields (up to 99 %) with excellent diastereo‐ and enantioselectivities (up to >19:1 d.r., 99 % ee). |
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| Keywords: | asymmetric catalysis heterocycles iron multicomponent reactions scandium |
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