Excellent correlation between drug release and portal size in metalla-cage drug-delivery systems |
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Authors: | Barry Nicolas P E Zava Olivier Dyson Paul J Therrien Bruno |
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Institution: | Institute of Chemistry, University of Neuchatel, Neuchatel, Switzerland. |
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Abstract: | A series of large cationic hexanuclear metalla-prisms, Ru(6)(p-iPrC(6)H(4)Me)(6)(tpt)(2)(donq)(3)](6+), Ru(6)(p-iPrC(6)H(4)Me)(6)(tpt)(2)(doaq)(3)](6+) and Ru(6)(p-iPrC(6)H(4)Me)(6)(tpt)(2)(dotq)(3)](6+), composed of p-cymene-ruthenium building blocks bridged by OO∩OO ligands (donq=5,8-dioxido-1,4-naphthoquinonato; doaq=5,8-dioxido-1,4-anthraquinonato, dotq=6,11-dioxido-5,12-naphthacenedionato) and connected by two 2,4,6-tripyridin-4-yl-1,3,5-triazine (tpt) panels, which encapsulate the guest molecules 1-(4,6-dichloro-1,3,5-triazin-2-yl)pyrene and Pd(acac)(2), have been prepared. The host-guest properties of these water-soluble delivery systems were studied in solution by NMR and fluorescence spectroscopy, providing the stability constants (K) for these host-guest systems. Moreover, the ability of the hosts to deliver the guests into cancer cells was evaluated and the uptake mechanism studied; the rate of release of the guest molecule was found to depend on the portal size of the host. |
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Keywords: | bioorganometallic chemistry drug delivery endocytosis host–guest systems ruthenium |
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