Highly Active Organocatalysts for Asymmetric anti-Mannich Reactions |
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| Authors: | Martín-Rapún Rafael Fan Xinyuan Sayalero Sonia Bahramnejad Mahboubeh Cuevas Félix Pericàs Miquel A |
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| Affiliation: | 1. Institute of Chemical Research of Catalonia (ICIQ), Av. Pa?sos Catalans 16, 43007 Tarragona (Spain), Fax: (+34)?977‐920‐222;2. Departament de Química Orgànica, Universitat de Barcelona, 08028 Barcelona (Spain) |
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| Abstract: | Lighten the load! A family of enantiopure 4-oxy-substituted 3-aminopyrrolidines arising from the enantioselective ring-opening of meso-3-pyrroline oxide have been developed as catalysts for the asymmetric, anti-selective Mannich reaction (see scheme; PMP=p-methoxyphenyl; PG=protecting group). Very high catalytic activity (down to 0.01 mol?% loading) and stereoselectivity have been recorded. |
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| Keywords: | asymmetric catalysis desymmetrization mannich reactions organocatalysis ring‐opening |
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