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Synthesis and BK channel-opening activity of novel N-acylhydrazone derivatives from dehydroabietic acid |
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| Authors: | Xia-Shi Lv Yong-Mei Cui He-Yun Wang Hai-Xia Lin Wei-Ya Ni Tomohiko Ohwada Katsutoshi Ido Kohei Sawada |
| Affiliation: | [1]Department of Chemistry, College of Sciences, Shanghai University, Shanghai 200444, China [2]Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan [3]Tsukuba Research Laboratories, Eisai Co. Ltd, lbaraki 300-2635, Japan |
| Abstract: | A series of hydrazone and N-acylhydrazone derivatives of dehydroabietic acid were synthesized and evaluated for BK channel-opening activities in an assay system of CHO-K1 cells expressing hBKα channels. The assay results indicated that the activities of the investigated compounds were influenced by the physicochemical properties of the substituent at hydrazone moiety. |
| Keywords: | BK channels Openers Dehydroabietic acid N-Acylhydrazone |
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