Synthesis and biological evaluation of novel 1,2,4-triazole containing 1,2,3-thiadiazole derivatives |
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Authors: | Yue-Dong Li Wu-Tao Mao Zhi-Jin Fan Juan-Juan Li Zhen Fang Xiao-Tian Ji Xue-Wen Hua Guang-Ning Zong Feng-Yun Li Chao-Lun Liu Jian-Hua Yu |
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Institution: | [1]State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China [2]Division of Hematology, College of Medicine and School of Public Health, The Ohio State University, Columbus, OH 43210, United States |
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Abstract: | A series of novel 1,2,4-triazoles containing 1,2,3-thiadiazole derivatives were designed and synthesized. Their structures were confirmed by melting points, IR, 1H NMR, and elemental analysis and ESI-MS or HRMS. Preliminary bioassays indicated that these compounds exhibited very good insecticidal activity against Aphis laburni at 100 μg/mL, with mortality no less than 95%. Compounds 6a, 6c, 6f, 6l showed higher curative activity against TMV and compound 6h showed a higher induction effects against TMV in vivo at 100 μg/mL. Collectively, our data demonstrate a new strategy for control of insects and viruses. |
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Keywords: | 1 2 3-Thiadiazole 1 2 4-Triazole Insecticidal activity Anti-TMV activity |
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