Separation of two labeled components of [111In] -OctreoScan by HPLC |
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| Authors: | A Bruskin V Tolmachev J-E Westlin H Lundqvist |
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| Institution: | (1) Institute of Theoretical and Experimental Physics (ITEP), Moscow, Russia;(2) Sections of Biomedical Radiation Sciences, Uppsala University, S-751 85 Uppsala, Sweden;(3) Department of Oncology, Radiology and Clinical Immunology, Rudbecklaboratoriet, Uppsala University, S-751 85 Uppsala, Sweden |
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| Abstract: | 111In]-DTPA-D-Phe1-octreotide (OctreoScan®, Mallinkrodt) is widely used for detection of neuroendocrine tumors and has lately been proposed for radionuclide therapy. We found, using HPLC and a GF-250 column (Zorbax®, Hewlett Packard), that OctreoScan® can be separated in two radiolabeled components of about equal amount. The analytical conditions for a quantitative isolation indicate that the two-peptide components of OctreoScan®have different lipophilicity. The isolated components are stable and do not transform into each other at room temperature during 6 hours (shelf-life of OctreoScan®). |
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