| 流动注射在线过滤稀释原子吸收法测定药物制剂中卡托普利 |
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| 引用本文： | 李亚荣,郎惠云,谭峰,焦更生.流动注射在线过滤稀释原子吸收法测定药物制剂中卡托普利[J].分析化学,2002,30(2):165-168. |
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| 作者姓名： | 李亚荣 郎惠云 谭峰 焦更生 |
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| 作者单位： | 1. 西北大学化学系,西安,710069
2. 渭南师范学院化学系,渭南,714000 |
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| 摘 要： | 提出了卡托普利的FI-AAS分析新方法。它是基于在适当酸度条件下卡托普利将Cu^2 还原为Cu^ ，新生的Cu^ 与SCN^-生成白色沉淀，经流动注射在线过滤稀释，以AAS法测定反应剩余Cu^2 的量来间接测定卡托普利的量。在2～100mg/L范围内呈良好的线性关系，回收率为97.1%～99.5%，采样频率为100h^-1。方法简单、快速、选择性好，节省试剂，用于卡托普利的测定，获得满意结果。
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| 关 键 词： | 流动注射 在线过滤 原子吸收光谱法 卡托普利 药物制剂 血管紧张素转移酶抑制剂 测定 分析 |
Determination of Captopril by Flow Injection On-line Filtration-Dilution Atomic Absorption Spectrometry |
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| Li Yarong,Lang Huiyun,Tan Feng,Jiao Gengsheng.Determination of Captopril by Flow Injection On-line Filtration-Dilution Atomic Absorption Spectrometry[J].Chinese Journal of Analytical Chemistry,2002,30(2):165-168. |
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| Authors: | Li Yarong Lang Huiyun Tan Feng Jiao Gengsheng |
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| Institution: | Li Yarong,Lang Huiyun,Tan Feng,Jiao Gengsheng 1 |
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| Abstract: | A simple, rapid and high selective method for the assay of captopril has been developed. It is based on the reaction of captopril with Cu2 and SCN-to form precipitate quantitatively in aqueous solution. The amount of residual Cu2 + can he determined by flow injection on-line filtration-dilution-atomic absorption spectrometry, then the content of captopril can be determined indirectly. The linear range is 2-100 mg/L, the recovery is 97. 1 %-99.5%, the sampling frequency is 100/h. The method has been applied to determine captopril with satisfactory result. |
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| Keywords: | Flow-Injection on-line filtration-dilution atomic absorption spectrometry captopril |
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