|
|||||
|
|
Regio-selective synthesis of novel 1-tert-butyl-4-nitro-1H-pyrrole-3-carboxylic acid building block |
|
| Authors: | Duyan V. Nguyen Robert A. Schiksnis Enrique L. Michelotti |
| Affiliation: | aDepartment of Chemistry, Locus Pharmaceuticals, Four Valley Square, 512 Township Line Road, Blue Bell, PA 19422, USA |
| Abstract: | A convenient, regio-selective synthesis of novel 1-tert-butyl-4-nitro-1H-pyrrole-3-carboxylic acid was developed, utilizing the bulky tert-butyl moiety of 1-tert-butyl-1H-pyrrole to direct selective, un-symmetrical substitutions to the desired 3 and 4 positions. |
| Keywords: | 1-tert-Butyl-4-nitro-1H-pyrrole-3-carboxylic acid Electrophilic substitution Regio-selective |
| 本文献已被 ScienceDirect 等数据库收录！ | |