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Model system for targeted drug release triggered by immune-specific signals |
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| Authors: | Shay Mailloux Nataliia Guz Maria Gamella Carballo José M Pingarrón Evgeny Katz |
| Institution: | 1. Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY, 13699-5810, USA 2. Department of Analytical Chemistry, Complutense University of Madrid, 28040, Madrid, Spain |
| Abstract: | A new sense-and-act system was realized by integrating a biocatalytic/bioaffinity electrode responding to immune signals represented by an antibody and a polymer-modified electrode loaded with drug-mimicking species. The release of the drug-mimicking species was achieved specifically in response to a signal antibody, thus demonstrating for the first time an immune-induced drug-releasing process. The present approach promises new options for future applications in controlled drug release and personalized medicine. Electrochemical immune-sensing system was integrated with the substance-releasing modified electrode to demonstrate the immune-triggered drug release process |
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