A facile one-pot preparation of 2-methyl-and 2-phenyl-4- fluoro-5-trifluoromethyl-6-methoxypyrimidine from methyl 2-hydryl-2-(F-methyl)-F-propyl ether |
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Authors: | Yoshio Inouye Yoichi Higuchi |
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Affiliation: | Department of Resources and Environment Science, Tokai University, 1117 Kita-Kaname, Hiratsuka-shi, Kanagawa 259-12 Japan |
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Abstract: | The title compounds were readily prepared in one-pot by phase-transfer reaction of a methanol adduct of 2-(-methyl)-- propene with acetamidine or benzamidine in the presence of aqueous sodium hydroxide in CH2Cl2. Various 5-trifluoromethyl- pyrimidines were also synthesized nucleophilic substitution of the 4-fluorine of the title compounds. |
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