Synthesis of useful building blocks for monofluorinated compounds derived from trifluoroethene |
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| Authors: | Yoshimichi Nakayama Tomoya Kitazume Nobuo Ishikawa |
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| Affiliation: | Department of Chemical Technology, Tokyo Institute of Technology, Ookayama, Meguro-ku, Tokyo 152 Japan |
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| Abstract: | A synthetic approach to monofluorinated compounds starts from the Friedel-Crafts acylhalogenation of trifluoroethene to give chlorotrifluoroketones and thence trifluorovinyl ketones. These are converted to phenylthio-adducts and thence monofluorinated α, β-unsaturated phenylthioesters, which by reduction afford β-fluoroallylic alcohols. |
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