The preparation of fluoroarenes by the catalytic decarboxylation of aryl fluoroformates |
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Authors: | David P Ashton TAnthony Ryan Brian R Webster Brett A Wolfindale |
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Institution: | Imperial Chemical Industries Plc, New Sciencs Group, The Heath, Runcorn, Cheshire, WA7 4QE U.K. |
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Abstract: | The catalytic decarboxylation of phenyl fluoroformate to fluorobenzene has been achieved with yields of 70–80% in a flow system using alumina or alumina-based catalysts. The reaction occurs in short space times (<1 s) and with optimal efficiency at ca. 300 °C (some 500 °C lower than the temperature required for the thermal decomposition of the fluoroformate). Impregnation of the alumina with a platinum group metal gave the following order of catalytic activity; Pt/Al2O3>Pd/Al2O3>Rh/Al2O3≈Al2O 3.2,4,6-Trimethlyphenyl flouroformate, a new material, was found to decarboxylate similarly to give 1-flouro-2,4,6-trimethylbenzene, but 4-chlorophenyl flouroformate was noted to produce only low yields (~10%) of the corresponding arly flouride |
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Keywords: | Author to whom correspondence should be addressed |
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