Damage effects of γ-radiation on lipid bilayers |
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Authors: | G. Erriu S. Onnis N. Zucca M. Casu A. Lai C. Giori G. Schianchi |
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Affiliation: | (1) Istituto di Fisica Medica dell’Università, 09125 Cagliari, Italia;(2) Dipartimento di Scienze Chimiche dell’Università, 09124 Cagliari, Italia;(3) Istituto di Scienze Fisiche dell’Università, 43100 Parma, Italia |
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Abstract: | Summary The lipid composition of multi-lamellar vesicles of 1,2-dipalmitoyl-sn-glycero-3-phosphorylcholine exposed to137Cs γ-rays depends on the absorbed dose. In fact,31P and1H NMR analysis shows that four new molecular species are formed during the irradiation:a) 1-palmitoyl-sn-glycero-3-phosphorylcholine,b) 2-palmitoyl-sn-glycero-3-phosphorylcholine,c) glycerophosphorylcholine andd) free palmitic acid. Neglecting the speciesc), that is present only at high dose and in very small amount, the behaviour of molar fractionvs. dose is sublinear fora) andb), while ford) it is almost linear over all the dose range examined. The molecular and structural damage consequences onto the multi-lamellar vesicles, evidentiated by spin-labelling and DSC techniques, are discussed. It is clearly shown in particular, that the behaviour of the main transition does not depend on the concentration of the lysolecithins, but rather on that of the free palmitic acid, the role of which had previously been entirely neglected. The authors of this paper have agreed to not receive the proofs for correction. |
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Keywords: | Biological effects of radiations |
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