炔雌醇类似物分子印迹聚合物的制备及性能研究

采用沉淀聚合法合成了以炔雌醇类似物17-乙基雌二醇为名义模板分子,甲基丙烯酸为功能单体,三羟甲基丙烷三甲基丙烯酸酯为交联剂的分子印迹聚合物微球。采用Gaussian 03计算机软件模拟了名义模板与功能单体的相互作用,优选功能单体及配比。利用透射电子显微镜观察了聚合物微球的形貌,通过静态平衡吸附试验研究了此聚合物对自身模板、炔雌醇及雌二醇的结合能力和选择性。结果表明印迹聚合物微球大小比较均匀,外形圆整,对炔雌醇及其类似物均表现出了较高的亲和性和特异性识别能力。

Studies on preparation and performances of analogue of ethinylestradiol molecularly imprinted polymers

A molecularly imprinted polymers(MIPs)was prepared by precipitation polymerization using 17-ethyl estradiol as the nominal template molecule,methacrylic acid as the functional monomer,trimethylolpropane trimethacrylate as the cross-linker.A molecular modeling approach was used to elucidate template-monomer interaction,and to optimize monomer.The morphous of MIPs was evaluated by transmission electron microscope(TEM).The particles were highly spherical.Data from static adsorption experiment indicated that the MIPs had high affinity and specific recognizablility to ethinylestradiol and its analogues.