| 改性羟基磷灰石/聚乳酸(PLLA)复合材料的制备及细胞毒性 |
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| 引用本文： | 戴延凤,张好宾,魏俊超,吴婷珍. 改性羟基磷灰石/聚乳酸(PLLA)复合材料的制备及细胞毒性[J]. 南昌大学学报(理科版), 2012, 36(4): 359-362 |
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| 作者姓名： | 戴延凤 张好宾 魏俊超 吴婷珍 |
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| 作者单位： | 南昌大学化学系 |
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| 基金项目： | 江西省自然科学基金资助项目 |
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| 摘 要： | 制备了一种表面接枝聚(γ-苄基-L-谷氨酸)的改性纳米羟基磷灰石(PBLG-g-HA),利用红外光谱(FT-IR)、X射线光电子能谱(XPS)证明了聚(γ-苄基-L-谷氨酸)(PBLG)成功的接枝在羟基磷灰石表面,TGA结果显示PBLG的接枝量为33.6%。通过溶剂复合法制得了PBLG-g-HA/PLLA复合材料,并通过MTT法对所制备的复合材料的细胞毒性进行了研究。结果表明,PBLG-g-HA/PLLA复合材料具有良好的生物相容性、能够促进成骨细胞增殖。更多还原
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| 关 键 词： | 羟基磷灰石 表面改性 聚乳酸 复合材料 细胞毒性 |
Preparation and cytotoxicity of modified hydroxyapatite/Poly (L-lactide) composites |
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| DAI Yan-feng , ZHANG Hao-bin , WEI Jun-chao , WU Ting-zhen. Preparation and cytotoxicity of modified hydroxyapatite/Poly (L-lactide) composites[J]. Journal of Nanchang University(Natural Science), 2012, 36(4): 359-362 |
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| Authors: | DAI Yan-feng ZHANG Hao-bin WEI Jun-chao WU Ting-zhen |
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| Affiliation: | (Department of Chemistry,Nanchang University,Nanchang 330031,China) |
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| Abstract: | A kind of poly(γ-benzyl-L-glutamate) modified hydroxyapatite was prepared.Fourier transform infrared(FT-IR) spectroscopy,X-ray photoelectron spectroscopy(XPS) showed that PBLG was successfully grafted.The thermal gravimetric analysis(TGA) results indicated that the surface grafting amount of PBLG-g-HA was about 33.6%.PBLG-g-HA/poly(L-lactide)(PLLA) nanocomosites were prepared via solvent-mixing method.Cell culture tests and MTT assessments showed that PBLG-g-HA/PLA composites possessed excellent biocompatibility and promote the adhesion and proliferation of osteoblast. |
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| Keywords: | hydroxyapatite surface modification poly(L-lactide) composites cytotoxicity |
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