中药炮制过程化学机理研究

中药炮制是中国的一项传统制药技术,也是中药区别于天然药物的显著特点。中药材经过加工炮制以后发生了复杂的化学变化,随着这些化学变化而改变的物质基础是中药炮制前后性味、功能改变的重要原因。阐明中药炮制过程中发生的这些化学变化是中药炮制机理研究的主要内容。近年来,国内外很多研究机构对中药炮制过程的化学机理进行了深入研究,初步阐明了多味中药炮制过程中发生的化学反应及化学成分变化,主要的化学反应包括水解反应、氧化反应、置换反应、异构化反应和分解反应等。本文对近年来中药炮制过程中化学反应机理领域取得的研究成果进行了综述,并对中药炮制过程化学机理研究的方向及前景进行了探讨。

Chemical Mechanism During Chinese Medicine Processing

Chinese medicine processing is a traditional Chinese pharmaceutical technology,and it is also the main characteristic property that distinguish traditional Chinese medicine and natural medicine.There are complex chemical changes during the process of Chinese medicine processing,and these chemical constituents which changed during processing maybe the basis of clinical efficacy changes.To clarify the changes of the chemical constituents and the chemical reactions in Chinese medicine during the processing process is the main purpose of the chemical mechanism research of Chinese medicine processing.In recent years,many research institutions at home and abroad have done deeply research in chemical mechanism during the process of Chinese medicine processing.The chemaical reactions and chemical mechanisms ocurred in some traditional Chinese medicines during the process of Chinese medicine processing were initially clarified.The main chemical reactions occurred in the Chinese medicine processing are hydrolysis reaction,oxidation reaction,replacement reaction,isomerization reaction,decomposition reaction,etc.The main achievements in the chemical mechanism research during the process of Chinese medicine processing are reviewed.The research directions and future in the chemical mechanism research of Chinese medicine processing are prospected.