The effect of Cu(II) ions on dopaquinone cyclization |
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| Institution: | 1. Jiangsu Key Laboratory of New Power Batteries, Laboratory of Electrochemistry, College of Chemistry and Materials Science, Nanjing Normal University, 122 Ninghai Road, Nanjing 210097, PR China;2. College of Chemistry and Material Science, South-Central University for Nationalities, Wuhan 430074, PR China;1. Bioactive Molecules Research Laboratory, Doctoral School of Sciences and Technologies, Faculty of Sciences, Lebanese University, Lebanon;2. Laboratory of Automatic Control, Chemical and Pharmaceutical Engineering, Claude Bernard Lyon 1 University, France;1. Department of Pharmaceutical Sciences, North South University, Bashundhara, Dhaka, Bangladesh;2. National University, Gazipur, Bangladesh |
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| Abstract: | The kinetics of the dopaquinone cyclization in the absence and presence of Cu(II) ions at pHs from 6 to 7.4 has been studied by cyclic, normal and reverse pulse voltammetry. Distinct inhibition of the dopaquinone ring closure reaction was observed in the. presence of Cu(II) ions. At pHs below 6 this effect is attributed to the formation of amino acid type complexes. At pH 7.4 the amino acid type and the catechol type Cu(II)-DOPA chelates coexist, and simultaneous interactions of copper ions with both ends of the DOPA molecule result in the association of the Cu(II)-DOPA complexes. These effects, observed at physiological pH, suggest that the rate of melanin formation is affected by the presence of Cu(II) ions. |
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