| (英)硫代氨基甲酸酯和草酰胺酯的合成、表征及抑菌活性 |
| |
| 引用本文： | 陈文彬,曹立,王勇.(英)硫代氨基甲酸酯和草酰胺酯的合成、表征及抑菌活性[J].化学通报,2015,78(1):29-36. |
| |
| 作者姓名： | 陈文彬 曹立 王勇 |
| |
| 作者单位： | 1. 元素有机化学国家重点实验室南开大学 天津 300071
2. 天津农科院植物保护研究所 天津 300192 |
| |
| 基金项目： | 天津市自然科学基金重点项目No. 12JCZDJC22000 |
| |
| 摘 要： | 为发现具有农业生物活性的先导化合物,本文以三聚光气和草酸二乙酯或乙基草酰氯为酰化试剂,在不同条件下合成了硫代氨基甲酸酯和草酰胺酯或草酰苯胺酯,所有目标化合物的结构都经过质谱、1H NMR和13C NMR表征。生物活性测试表明,硫代氨基甲酸酯1b和1f在浓度为6.25 mg/L时,表现出较好的体外抑菌活性,而草酰胺酯和草酰苯胺酯没有表现出任何农业生物活性。
|
| 关 键 词： | 硫代氨基甲酸酯 草酰胺酯 草酰苯胺酯 三光气 合成 生物活性 |
| 收稿时间： | 4/9/2014 12:00:00 AM |
| 修稿时间： | 2014/5/12 0:00:00 |
Synthesis, characterization and antifungal activities of thiocarbamates and oxamate |
| |
| Chen Wenbin,Cao Li and Wang Yong.Synthesis, characterization and antifungal activities of thiocarbamates and oxamate[J].Chemistry,2015,78(1):29-36. |
| |
| Authors: | Chen Wenbin Cao Li and Wang Yong |
| |
| Institution: | Chen Wenbin;Cao Li;Wang Yong;State Key Laboratory of Elemento-Organic Chemistry,Nankai University;Tianjin Institute of Plant Protection,Tianjin Academy of Agricultural Sciences; |
| |
| Abstract: | In this paper, thiocarbamates and oxamates or oxanilates were synthesized using triphosgene and diethyl oxalate or ethyl oxalyl chloride, respectively, under different conditions for pursuing new lead compounds with agricultural activities. All the title compounds were characterized by mass spectrometry, 1H and 13C NMR spectroscopy, respectively. Biological essay results showed that thiocarbamates 1b and 1f possessed good antifungal activities in vitro at 6.25 mg/L, while oxamates and oxanilates do not possess any activity in agriculture. |
| |
| Keywords: | Thiocarbamate Oxamate Oxanilate Triphosgene Synthesis Biological Activities |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《化学通报》浏览原始摘要信息 |
| 点击此处可从《化学通报》下载免费的PDF全文 |
