Metalloantimalarials: synthesis and characterization of a novel agent possessing activity against Plasmodium falciparum |
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| Authors: | Ocheskey Joseph A Harpstrite Scott E Oksman Anna Goldberg Daniel E Sharma Vijay |
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| Institution: | Mallinckrodt Institute of Radiology, Washington University Medical School, St. Louis, MO, USA. |
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| Abstract: | The synthesis, characterization, and antimalarial potency of an amine-phenol complex of gallium(III), {1,12-bis(2-hydroxy-3-methoxy-5-(quinolin-3-yl)-benzyl)-1,5,8,12-tetraazadodecane}-gallium(III)]+, Ga-3-M-5-Quadd]+ (7) is described; a novel agent that targets Plasmodium falciparum strains. |
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