A Simple Nickel Catalyst Enabling an E-Selective Alkyne Semihydrogenation |
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Authors: | Niklas O Thiel Benyapa Kaewmee Trung Tran Ngoc Prof?Dr Johannes F Teichert |
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Institution: | 1. Institut für Chemie, Technische Universität Berlin, Strasse des 17. Juni 115, 10623 Berlin, Germany;2. Institut für Chemie, Technische Universität Berlin, Strasse des 17. Juni 115, 10623 Berlin, Germany
These authors contributed equally to this work. |
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Abstract: | Stereoselective alkyne semihydrogenations are attractive approaches to alkenes, which are key building blocks for synthesis. With regards to the most atom-economic reducing agent dihydrogen (H2), only few catalysts for the challenging E-selective alkyne semihydrogenation have been disclosed, each with a unique substrate scope profile. Here, we show that a commercially available nickel catalyst facilitates the E-selective alkyne semihydrogenation of a wide variety of substituted internal alkynes. This results in a simple and broadly applicable overall protocol to stereoselectively access E-alkenes employing H2, which could serve as a general method for synthesis. |
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Keywords: | alkynes catalysis hydrogenation nickel stereoselectivity |
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