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Designed Boron-Rich Polymeric Nanoparticles Based on Nano-ion Pairing for Boron Delivery |
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| Authors: | Jianwei Li Dr. Olga Janoušková Roberto Fernandez-Alvarez Soňa Mesíková Dr. Zdeněk Tošner Dr. Sami Kereïche Dr. Mariusz Uchman Prof. Pavel Matějíček |
| Affiliation: | 1. Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Hlavova 2030, 128 43 Prague 2, Czech Republic;2. Institute of Macromolecular Chemistry, v.v.i., Academy of Sciences of the Czech Republic, Heyrovský Sq. 2, 16206 Prague 6, Czech Republic;3. NMR laboratory, Faculty of Science, Charles University in Prague, Hlavova 2030, 128 43 Prague 2, Czech Republic;4. Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Hlavova 2030, 128 43 Prague 2, Czech Republic Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Purkynie Ustav, Albertov 4, 12 801 Prague, Czech Republic |
| Abstract: | Boron-rich particles with the boron fraction ca.10–20 wt % of controllable shape and size that can be easily prepared via simple ion co-assembly are promising material for tumor treatment by boron neutron capture therapy. Electroneutral, dynamic core-shell polymeric nanoparticles were prepared by co-assembly of cationic PEO-block-PGEA diblock copolymer with sodium closo-dodecaborate, Na2[B12H12]. This is the first example of polymer nanoparticles based on [B12H12]2−nano-ion pairing. The high [B12H12]2− loading is proven by calorimetry at physiological salt concentration. As a result of rational design, rod-, worm- and sphere-like particles were produced and further tested using human glioblastoma and cervical carcinoma cell lines. Rod-like particles yielded the highest internalization capability in all tested cell lines. |
| Keywords: | boron neutron capture therapy boron cluster compounds nano-ions polymer nanoparticles self-assembly |