Photoredox-Catalyzed Addition of Carbamoyl Radicals to Olefins: A 1,4-Dihydropyridine Approach |
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Authors: | Luana Cardinale Dr Mikhail O Konev Prof Dr Axel Jacobi von Wangelin |
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Institution: | Dept. of Chemistry, University of Hamburg, Martin Luther King Pl 6, 20146 Hamburg, Germany |
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Abstract: | Functionalization with C1-building blocks are key synthetic methods in organic synthesis. The low reactivity of the most abundant C1-molecule, carbon dioxide, makes alternative carboxylation reactions with CO2-surrogates especially important. We report a photoredox-catalyzed protocol for alkene carbamoylations. Readily accessible 4-carboxamido-Hantzsch esters serve as convenient starting materials that generate carbamoyl radicals upon visible light-mediated single-electron transfer. Addition to various alkenes proceeded with high levels of regio- and chemoselectivity. |
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Keywords: | 1 4-dihydropyridines carbamoyl radicals Giese reaction organic dyes photoredox catalysis |
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