A Selective Sulfide Oxidation Catalyzed by Heterogeneous Artificial Metalloenzymes Iron@NikA |
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Authors: | Dr. Sarah Lopez Dr. Caroline Marchi-Delapierre Dr. Christine Cavazza Dr. Stéphane Ménage |
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Affiliation: | CEA, CNRS, IRIG, CBM, Univ. Grenoble Alpes, 38000 Grenoble, France |
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Abstract: | Performing a heterogeneous catalysis with proteins is still a challenge. Herein, we demonstrate the importance of cross-linked crystals for sulfoxide oxidation by an artificial enzyme. The biohybrid consists of the insertion of an iron complex into a NikA protein crystal. The heterogeneous catalysts displays a better efficiency-with higher reaction kinetics, a better stability and expand the substrate scope compared to its solution counterpart. Designing crystalline artificial enzymes represents a good alternative to soluble or supported enzymes for the future of synthetic biology. |
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Keywords: | artificial metalloenzymes bioinspired catalyst crystal catalysis oxidation sulfoxidation k |
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