Inertial microfluidics: Recent advances |
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| Authors: | Di Huang Jiaxiang Man Di Jiang Jiyun Zhao Nan Xiang |
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| Affiliation: | 1. College of Mechanical and Electrical Engineering, China University of Mining and Technology, Xuzhou, P. R. China;2. College of Mechanical and Electrical Engineering, China University of Mining and Technology, Xuzhou, P. R. China Jiangsu Province and Education Ministry Co-sponsored Collaborative Innovation Center of Intelligent Mining Equipment, China University of Mining and Technology, Xuzhou, P. R. China;3. School of Mechanical and Electronic Engineering, Nanjing Forestry University, Nanjing, P. R. China;4. School of Mechanical Engineering, Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments, Southeast University, Nanjing, P. R. China |
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| Abstract: | Inertial microfluidics has attracted significant attentions in last decade due to its superior advantages of high throughput, label- and external field-free operation, simplicity, and low cost. A wide variety of channel geometry designs were demonstrated for focusing, concentrating, isolating, or separating of various bioparticles such as blood components, circulating tumor cells, bacteria, and microalgae. In this review, we first briefly introduce the physics of inertial migration and Dean flow for allowing the readers with diverse backgrounds to have a better understanding of the fundamental mechanisms of inertial microfluidics. Then, we present a comprehensive review of the recent advances and applications of inertial microfluidic devices according to different channel geometries ranging from straight channels, curved channels to contraction-expansion-array channels. Finally, the challenges and future perspective of inertial microfluidics are discussed. Owing to its superior benefit for particle manipulation, the inertial microfluidics will play a more important role in biology and medicine applications. |
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| Keywords: | Applications Cell separation Inertial Microfluidics Particle manipulation |
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