Ruthenium-Induced Cyclization of Heteroatom-Functionalized Alkynes: Progress,Challenges and Perspectives |
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Authors: | Dr Lai-Hon Chung Chi-Fung Yeung Dr Chun-Yuen Wong |
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Institution: | Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Hong Kong, SAR, P. R. China |
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Abstract: | Metal-induced cyclization of functionalized alkynes represents one of the most general approaches to prepare organic heterocycles. Although RuII centers are well-established to promote alkyne to vinylidene rearrangements and many RuII-mediated alkyne cyclizations have been rationalized to be the results of post-vinylidene transformations, recent discoveries indicate that RuII centers can serve as electrophiles and induce alkyne cyclizations without vinylidene intermediacy. In this Minireview, an overview of the RuII-induced cyclization of heteroatom-functionalized alkynes in the last decade is provided, with an emphasis on the discoveries and validations of the unconventional “non-vinylidene-involving” pathways. |
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Keywords: | alkynes cyclization reaction mechanisms ruthenium vinylidene |
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