The Synthesis of Warfarin Using a Reconfigurable-Reactor Platform Integrated to a Multiple-Variable Optimization Tool |
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| Authors: | Jee Seong Kwak Nour Bizarri Dr Sepideh Sharif Wenyao Peter Zhang Dr Debasis Mallik Prof Michael G Organ |
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| Institution: | 1. Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario, M3J1P3 Canada
Centre for Catalysis Research and Innovation (CCRI) and Department of Chemistry and Biomolecular Sciences, University of Ottawa, 10 Marie Curie, Ottawa, Ontario, K1N6N5 Canada;2. Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario, M3J1P3 Canada |
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| Abstract: | Optimization of the asymmetric synthesis of warfarin, an important anticoagulant, has been evaluated using a reconfigurable reaction platform capable of performing batch, continuous flow, and plug-flow synthesis. Further, this platform has been integrated with a novel, multidimensional, multiple variable analysis tool that can evaluate multiple critical quality attributes (CQA), percent conversion and enantiomeric excess in this case, from a single injection that is repeatedly recycled in a closed loop of chromatography columns, a detector and a heart-cut valve. Further, the new, integrated analysis system also facilitates validation of each QA, providing a high-level of confidence in analytical measurements, which are obtained without operator intervention. |
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| Keywords: | flow chemistry multi-dimensional chromatography multiple critical quality attributes warfarin |
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