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Engineering a NO-Regulated Nanofluidic Sensor through the Cyclization Reaction Strategy |
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| Authors: | Yunfeng Han Prof. Zhongyue Sun Prof. Ziyan Sun Xiaoya Chen Prof. Yongxue Zhang Prof. Yao Sun Prof. Haibing Li |
| Affiliation: | 1. Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022 P. R. China Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030 P. R. China These authors contributed equally to this work.;2. Key laboratory of Pesticides and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079 P. R. China School of Laboratory Medicine, Hubei University of Chinese Medicine, Wuhan, 430065 P. R. China These authors contributed equally to this work.;3. Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030 P. R. China These authors contributed equally to this work.;4. Key laboratory of Pesticides and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079 P. R. China;5. Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022 P. R. China |
| Abstract: | Nitric oxide (NO) is known to be a secondary in vivo signaling agent, demonstrating various biological functions through regulating ion flux in channels. Considering the crucial role of NO in vivo, herein, a biomimetic NO-regulated nanofluidic sensor has been fabricated through a cyclization reaction strategy. This nanofluidic sensor exhibited a promising NO selectivity, sensitivity, and non-interference performance in complex matrices. Thus, such a NO-driven nanosensor will be meaningful for scientific researchers to grasp the in vivo functions of NO. |
| Keywords: | cyclization reactions ion rectification nanochannel nanosensors nitic oxide |