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Ruthenium(II)-Catalyzed Double Annulation of Quinones: Step-Economical Access to Valuable Bioactive Compounds |
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| Authors: | Prof Dr Eufrânio N da Silva Júnior Renato L de Carvalho Renata G Almeida Luisa G Rosa Dr Felipe Fantuzzi Dr Torben Rogge Pedro M S Costa Prof Dr Claudia Pessoa Prof Dr Claus Jacob Prof Dr Lutz Ackermann |
| Institution: | 1. Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077 Göttingen, Germany;2. Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077 Göttingen, Germany
Institute of Exact Sciences, Department of Chemistry, Federal University of Minas Gerais, UFMG, 31270-901 Belo Horizonte, MG, Brazil;3. Institute of Exact Sciences, Department of Chemistry, Federal University of Minas Gerais, UFMG, 31270-901 Belo Horizonte, MG, Brazil;4. Institute for Inorganic Chemistry, Julius-Maximilians-Universität Würzburg, Am Hubland, 97074 Würzburg, Germany;5. Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, 60430-270 Brazil;6. Division of Bioorganic Chemistry, School of Pharmacy, University of Saarland, 66123 Saarbrücken, Germany |
| Abstract: | Double ruthenium(II)-catalyzed alkyne annulations of quinones were accomplished. Thus, a strategy is reported that provides step-economical access to valuable quinones with a wide range of applications. C−H/N−H activations for alkyne annulations of naphthoquinones provided challenging polycyclic quinoidal compounds by forming four new bonds in one step. The singular power of the thus-obtained compounds was reflected by their antileukemic activity. |
| Keywords: | alkynes annulation C−H activation quinones ruthenium |