A Sunscreen-Based Photocage for Carbonyl Groups |
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Authors: | Mauricio Lineros-Rosa Prof Miguel A Miranda Dr Virginie Lhiaubet-Vallet |
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Institution: | Instituto Universitario Mixto de Tecnología Química (UPV-CSIC), Universitat Politècnica de València, Consejo Superior de Investigaciones Científicas, Avda de los Naranjos, s/n, 46022 Valencia, Spain |
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Abstract: | Photolabile protecting groups (PPGs) have been exploited in a wide range of chemical and biological applications, due to their ability to provide spatial and temporal control over light-triggered activation. In this work, we explore the concept of a new photocage compound based on the commercial UVA/UVB filter oxybenzone (OB; 2-hydroxy-4-methoxybenzophenone) for photoprotection and controlled release of carbonyl groups. The point here is that oxybenzone not only acts as a mere PPG, but also provides, once released, UV photoprotection to the carbonyl derivative. This design points to a possible therapeutic approach to reduce the severe photoadverse effects of drugs containing a carbonyl chromophore. |
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Keywords: | laser spectroscopy photocages photochemistry photoprotection solar filters |
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