Quality transitivity of Danhong Huayu Koufuye: A study on chemical profiles of medicinal herbs,compound preparation and dosed rat plasma using ultra-performance liquid chromatography–quadrupole time-of-flight mass spectrometry |
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Authors: | Hongbing Zhang Xin Wu Xinyi Liu Jun Xu Suxiao Gong Yanqi Han Tiejun Zhang Changxiao Liu |
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Institution: | 1. Tianjin Key Laboratory of Quality Markers of Traditional Chinese Medicine, Tianjin Institut e of Pharmaceutical Research, Tianjin, China
State Key Laboratoty of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China;2. Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China;3. School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China;4. Tianjin Key Laboratory of Quality Markers of Traditional Chinese Medicine, Tianjin Institut e of Pharmaceutical Research, Tianjin, China |
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Abstract: | Danhong Huayu Koufuye (DHK), an effective Chinese medicine preparation, is mainly used for the treatment of blurred vision and sudden blindness caused by qi stagnation and blood stasis, as well as the absorption period of central retinal vein occlusion. However, the current quality standard is relatively low, only stipulating the content of protocatechualdehyde. Chemical transitivity is the basis for discovering quality markers and is used in quality process control of Chinese medicines. Herein, the chemical profiles of seven medicinal herbs, DHK and dosed rat plasma were comprehensively analyzed using ultra-performance liquid chromatography–quadrupole time-of-flight mass spectrometry. As a result, 134 chemical constituents were identified in seven medicinal herbs, including salvianolic acids, diterpene quinones, phenolic acids, phthalides, cyanogenic glycosides, flavonoids and triterpenoid saponins. Among them, 55 chemical constituents were transferred to DHK along with extraction and preparation, and 26 were further absorbed into blood and metabolized to produce 11 metabolites after oral administration. The transitivity of DHK from medicinal herbs to compound preparation and into blood was analyzed for the first time. This article will be valuable to ascertain the quality markers for quality process control and further pharmacokinetic studies. |
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Keywords: | chemical profiles Danhong Huayu Koufuye mass spectrometry quality transitivity ultra-performance liquid chromatography |
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