Nickel-Catalyzed Amination of (Hetero)aryl Halides Facilitated by a Catalytic Pyridinium Additive |
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Authors: | Dongyang Han Sasa Li Siqi Xia Mincong Su Prof Dr Jian Jin |
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Institution: | 1. CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032 P. R. China;2. Center for Supramolecular Chemistry and Catalysis, Department of Chemistry, College of Sciences, Shanghai University, 99 Shangda Road, Shanghai, 200444 P. R. China |
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Abstract: | An efficient and operationally simple Ni-catalyzed amination protocol has been developed. This methodology features a simple NiII salt, an organic base and catalytic amounts of both a pyridinium additive and Zn metal. A diverse number of (hetero)aryl halides were coupled successfully with primary and secondary alkyl amines, and anilines in good to excellent yields. Similarly, benzophenone imine gave the corresponding N-arylation product in an excellent yield. |
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Keywords: | amination anilines aryl halides C−N coupling nickel catalysis |
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