Syntheses,characterization and DNA cleavage studies of acyclic copper(II) complexes |
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| Authors: | Xing-Man Xu Zong-Wan Mao Liang-Nian Ji Jun-Hua Yao Hong Li |
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| Institution: | (1) School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, 510275, PR China;(2) Instrumental Analysis and Research center, Sun Yat-sen University, Guangzhou, 510275, PR China;(3) Department of Chemistry, South China Normal University, Guangzhou, 510631, PR China |
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| Abstract: | Two novel acyclic copper(II) complexes, Cu(L1) (1) {L1 = N,N -1,2-ethanediylbisN-(phenylmethyl)glycinato]} and Cu(L2) (2), {L2 = N,N-1,2-ethanediylbisN-(3-nitrophenyl)methyl]glycinato]} have been synthesized and characterized by elemental analysis and ES-MS. Thermal denaturation, fluorescence spectroscopy and cyclic voltammetry have been conducted to assess the interaction of the two complexes with calf thymus DNA. Interestingly, the two copper(II) complexes have been found to cleave circular plasmid pBR322 DNA to the nicked form (Form II) and the linear form (Form III) under aerobic conditions. |
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