星型卟啉化聚(N-异丙基丙烯酰胺)的制备及应用

近几年来,卟啉化合物因其独特的光电化学性质,被广泛地应用于光动力学疗法(PDT)中.然而,绝大多数卟啉基化合物水溶性差,易发生低分子聚集分散不均的现象,限制其在PDT的应用.因此,利用卟啉化合物易于被修饰的特点,通过可逆加成裂解链转移自由基聚合法将含有-OH的卟啉与N-异丙基丙烯酰胺单体聚合形成温敏性聚合物(THPP-...

Preparation and Application of Star Porphyrinized Poly(N-isopropylacrylamide)

In recent years, porphyrin compounds have been widely used in photodynamic therapy(PDT) due to their unique photoelectrochemical properties.However, most porphyrin-based compounds have poor water solubility and are prone to uneven distribution of low-molecular aggregation, which limits their application in PDT. Therefore, this article takes advantage of the fact that porphyrin compounds are easily modified, and polymerizes-OH-containing porphyrin with N-isopropylacrylamide monomer to form a temperature-sensitive polymer(THPP) by reversible addition cleavage chain transfer radical polymerization-PAM₄. The temperature sensitivity of the copolymer was studied. The study showed that the copolymer had an LCST value of 32℃. The MTT test results showed that THPP-PAM₄ has good biocompatibility and low dark toxicity to L929 cells and HeLa cells. The phototoxicity to HeLa cells was significantly higher than that to L929 cells.